In late March, NIH issued a Sources Sought Notice (SSN) looking for info on a Web-based solution capable of handling electronic submission proposals for the complex mechanisms. These are funding mechanisms such as Program Projects which have not been converted to PureEdge or Adobe and are still submitted on paper using the PHS398 forms.
Cayuse responded enthusiastically to the SSN this week because it is aligned perfectly with what we do: eliminate paper and downloadable forms from the grants process.
My humble personal opinion is that the PDF-based approach is an interim solution. People collaborate and do business on the Web, and the Web is the way Grants.gov has to go. It's also how Cayuse424 works today, by the way. I'm happy to see NIH taking a serious look at leveraging this technology more fully.